Chapter 671 New mechanism of angiogenesis in liver cancer
She looked at it quickly.
It said: "I'm sorry to scare you. I may have died. Please contact the hospital. Thank you, Dr. Xu, and everyone at Linyi. I really want to be with Wenwen forever and watch my daughter grow up. I'm sorry."
The ICU nurse's breathing stagnated. She subconsciously pressed the other's shoulder. Before she could detect the breath and measure the temperature, she felt the stiffness that belonged to the corpse.
"Director!"
She rushed back to the ICU. Soon, a group of ICU doctors and nurses rushed out and surrounded the scene.
Not long after, the death notice signed by Xu Qiu himself was issued.
Two years have passed. This is the first time he has signed a death notice for a patient... Qiu Qinghu has too many miracles. He is the first subject of palmar finger regeneration surgery and the liver donor for piggyback living liver transplantation...
But all the historical status and honors are not as good as a summary in one sentence: a man, a great husband and father.
...
On this day, the atmosphere of Linyi was a bit dull.
Because Xu Qiu was the attending physician, Qiu Qinghu and Fang Wenwen received the attention of the entire hospital. In addition, their love story was so touching and they were very affectionate on weekdays. It was hard to tell that they were both dying of advanced cancer.
Therefore, when one of them died suddenly, everyone felt very bad.
But when a major car accident occurred and countless injured people were sent to the emergency department, everyone calmed down again and the entire hospital became busy.
A body was sent to the morgue, and in the obstetrics and gynecology delivery room not far away, scissors cut the umbilical cord and a new life came... In this hospital, death and rebirth always happen at the same time.
Xu Qiu also had no time to sigh. After signing the death notice, he turned to the rescue work in the emergency department.
It was already past eight o'clock in the evening when the emergency was handled.
"A total of 37 patients were sent here, two of whom died on the way, one was not saved after going on the stage, and the others were all out of danger..." reported the attending physician Yang Yuen.
Now, Yang Yuen has been promoted to the leader of the rescue team with his outstanding ability. There are also Jiang Mai, Shi Lian and others in the team, all of whom are doctors trained by Xu Qiu.
Wang Fan scratched his ear: "The one who was not saved was aortic dissection. He lost more than 3,000 milliliters of blood when he went on stage. There was really no way..."
"You have worked hard. Go back and rest." Xu Qiu nodded, gave a few instructions, and turned to the office.
Looking at Xu Qiu's back, Yang Yuen and others hesitated to speak.
After Xu Qiu walked away, Yunmei asked worriedly, "Doctor Xu still has to work overtime?"
Yang Yuen thought, "I guess so."
She raised her eyebrows at Shi Lian and said, "Xiao Shi, your teacher seems to have been working overtime these weeks, and you don't let him pay attention to rest."
Shi Lian said innocently, "I am also worried... The teacher has been running between the hospital and Baiyun Pharmaceutical Factory these days. I usually follow him and feel that he only sleeps for a while when he is in the car..."
Yunmei said worriedly, "This is definitely not okay. Doctor Xu is not Wang Fan. How can he treat himself like this? My own body!"
Wang Fan said with a dark face: "I'm still here."
Yang Yuen touched his chin and said: "Let's all work hard. If we can take over the emergency department as soon as possible, Dr. Xu will have less pressure and he should have more time to rest."
Shi Lian clenched his fist: "Yeah! Senior Sister Yang, I'll go to the operation with you. Can I try to be the main surgeon this time!"
Yun Mei looked at Shi Lian deeply, and was shocked in her heart... No wonder Xu Qiu was willing to accept Shi Lian as a student. The progress of this little girl is amazing. She can almost hold a scalpel before the internship is over.
This is the trend of becoming the second Xu Qiu!
...
At one o'clock in the night, the director's office was still bright.
Suddenly, there was a light knock on the door.
Xu Qiu put down the information in his hand and glanced at it. The desk was already full of various notes and drafts.
"Come in."
As soon as Xu Qiu's voice came up, the door was quickly pushed open, and Mo Wan rushed in excitedly, with an expression of uncontrollable excitement.
"Mo Wan?" Xu Qiu looked at him in confusion.
Mo Wan took a deep breath and said, "Doctor Xu, there is new progress in my experiment!"
Her research direction is also the development of liver cancer drugs. Academician Chen sent her here to assist Xu Qiu in developing liver drugs.
She has been unknown for the past few weeks.
But now there are finally results.
"Progress?" Xu Qiu stood up. Mo Wan's ability is not to be underestimated. She can come to inform overnight, so it must not be an insignificant discovery.
"Look!"
Mo Wan handed over a document.
This is the direction Xu Qiu gave her. The purpose is to find the important mechanism of liver cancer angiogenesis. If it succeeds, it will have a great driving effect on the research of liver cancer targeted drugs.
As we all know, liver cancer is a typical multi-vascular tumor. The growth, development and metastasis of liver cancer blood vessels are closely related to the formation of blood vessels.
Theoretically, if vascular endothelial growth factor, platelet-derived growth factor and fibroblast growth factor can be inhibited, the blood vessels and growth and metastasis of liver cancer can be inhibited, thereby controlling liver cancer.
Currently, many liver cancer targeted drugs are trying to overcome this mechanism.
However, the actual clinical objective remission rate is only about 10%, which is seriously inconsistent with the vascular mechanism of liver cancer.
Xu Qiu gave Mo Wan a new direction, intending to find a new mechanism for the formation of liver cancer blood vessels...
……
The data in front of her is exactly what Mo Wan has concluded under Xu Qiu's guidance these days.
And she lived up to expectations and discovered a new mechanism, or a new factor, for liver cancer angiogenesis for the first time.
Heparin-binding epidermal growth factor!
Mo Wan said excitedly: "This was discovered by accident when we were studying transmembrane serine protease 4!
"During the test at that time, we realized that there was a factor that was closely related to transmembrane serine protease 4, and this was a new factor that was not among the existing growth factors discovered!
"We then tried to find it, and finally an hour ago, we found it! It was heparin-binding epidermal growth factor!
"And the specific mechanism - transmembrane serine protease 4 can not only promote the expression of heparin-binding epidermal growth factor precursor, but also activate the EGFR/PI3K/AKT/mTOR signaling pathways, thereby promoting the enzymatic hydrolysis of heparin-binding epidermal growth factor precursor by MMP9...
"After dissolution, the factor becomes soluble heparin-binding epidermal growth factor, and this factor can promote liver cancer angiogenesis and help liver cancer invasion and metastasis!"
"..."
Looking at the information in his hand, Xu Qiu exerted a little force in his hand.
This research result is definitely a heavyweight discovery!
Moreover, it will also become an academic patent that countless pharmaceutical companies will compete to buy - the new mechanism means that there will be a new track for liver cancer drug research and development!
