Chapter 739 Xu Qiu's personal show

"This time's rubber artificial bone may be more advanced than the automatic craniotomy machine!" Academician Shen Hua's eyes lit up.

Lin Xie couldn't hide the smile on his face.

What can be developed behind the automatic craniotomy machine will definitely be better than the one in front.

It’s just...rubber artificial bone, what is rubber?

…

Everyone has similar questions in their minds.

What does the rubber in rubber artificial bone mean?

This name is undoubtedly eye-catching.

After a short wait, Xu Qiu began to introduce.

“Bone defect repair has always been one of the important issues in the medical community.

“With the global aging trend, the demand for bone defect repair and treatment is also increasing. More than 2.2 million bone grafting surgeries are performed every year. Due to the huge number of surgeries, the amount of autologous bone is becoming increasingly insufficient.

"Furthermore, autogenous bone is like tearing down one wall to make up for the other. The source is limited and the scope of repair is also limited. In this case, artificial bone has no limit on quantity and location, and it will not cause damage to the patient itself. It has already become one of the medical materials with the largest clinical application gap.

“However, clinical bone defects have various shapes, and there are many requirements for transplantation.

"The first is the shape of artificial bone. Bone repair materials must have plasticity, and the shape of the material can be adjusted repeatedly before implantation into the human body and during surgery, so that it can best match the defective site.

"Second point. Bone defects are usually accompanied by bleeding, abscesses, etc., and the surgical area is likely to be in a liquid environment. The product must have sufficient stability, that is, it must be resistant to liquid phase collapse and liquid erosion.

"Last point, bone filling materials can be degraded and regenerated in the human body..."

After listening to Xu Qiu's words, many doctors in the fields of orthopedic surgery, bone reconstruction and other fields fell silent.

These three points are only the most important three points. However, there is still no product on the market that can achieve these three points at the same time.

For example, conventional block and powder bone repair materials have the widest variety of materials, including allogeneic bone, allograft bone, bioceramics, inorganic salts and natural polymer mixtures, etc. It has strong stability. The liquid phase collapse resistance is very good, but the plasticity is poor, and most of them cannot be degraded, resulting in poor bone formation ability.

Bone cement, which is becoming more and more common in clinical practice, has achieved the best in terms of plasticity and resistance to liquid phase collapse. However, as its name suggests, bone cement itself cannot be degraded like cement.

Other material subsequently appeared.

For example, putty-like artificial bone uses bioceramic particles and water-soluble polymers. It can be degraded, but its resistance to liquid phase collapse is not good enough, and it cannot be used in a liquid environment.

The paste-like artificial bone has made improvements in its resistance to liquid collapse. As long as it is implanted after curing, it is not easily destroyed by the liquid environment. However, it cannot be reshaped repeatedly, and its plasticity will be lost with the loss of water. .

It can be said that today's bone reconstruction and bone repair fields are full of products that have their own advantages, but also have major disadvantages. There is still a blank of cutting-edge all-round products.

Xu Qiu also knows this.

He smiled and said:

"Rubber artificial bone was born under this background...

“It’s like plasticine and can be shaped at will with the help of tools or even with your hands, and the filling effect is excellent.

"On the premise that plasticity is guaranteed, it has excellent resistance to liquid phase collapse during healing, and can stabilize operations in various aqueous environments. Even massive bleeding, tissue fluid leakage, etc. will not affect its stability.

"Finally, it has excellent osteoconduction and osteoinduction capabilities, and can complete bone regeneration within three to six months after implantation!"

Hearing this, everyone showed shocked expressions and stared dumbly at the content displayed on the screen.

Osteoconduction and osteoinduction are the two most important mechanisms in the field of bone repair.

The former refers to bones growing from one side to the other, similar to the South-to-North Water Diversion Project.

Osteoinduction, on the other hand, induces the body to grow bone cells in a non-bone environment, which can be regarded as making something out of nothing.

Bone materials generally cannot satisfy these two requirements at the same time, and it is even more difficult to achieve a balance in the period. They either favor conductive growth, or induce a large number of bone cells to form in a non-bone environment.

But Xu Qiu’s rubber artificial bone actually found a balance between the two mechanisms? !

…

Xu Qiu stopped talking, and the giant screen silently displayed the details of the rubber artificial bone.

To everyone's surprise, this product does not use new materials, but uses a conventional material combination of polylactic acid and hydroxyapatite. By adjusting the monomer ratio and molecular weight, the softness, plasticity, stability, etc. of the material are improved. The control has reached a perfect point.

The old problem of hydroxyapatite materials is that after degradation, a large number of hydroxyl groups will be produced, resulting in an acid-base imbalance in the internal environment——

In this regard, Xu Qiu also used super-dispersion technology to evenly disperse fine hydroxyapatite particles in the polylactic acid material, which effectively neutralized acidic substances and also achieved the slow release of calcium ions during the degradation of hydroxyapatite. , which makes the calcium ion concentration in the surrounding tissue fluid relatively balanced, but promotes the osteogenesis efficiency!

Everyone was stunned.

What is the monomer ratio and to what extent has the molecular weight been adjusted?

There is also super-dispersion technology...how to operate it specifically?

They really wanted to understand all this, but these were the core secrets of the materials. How could Xu Qiu give them up?

"It turned out to be like this..."

"It's outrageous. He does scientific research not only to solve old problems, but every solution to the problem also provides great convenience for the final result!"

The contestants were dumbfounded and felt unbelievable.

Just like the degradation of hydroxyapatite material leads to acid-base imbalance, most people's idea is to solve the acid-base imbalance.

In fact, it is enough to control the hydroxyl content after degradation.

But Xu Qiu is not satisfied with this. While using ultra-dispersion technology to solve the acid-base imbalance problem, he also improves the sustained release of calcium ions during the degradation of hydroxyapatite, providing the best in vivo environment for osteogenesis...

This alone has surpassed most of the people present.

...

"Final score, 96 points."

With Beimudong's announcement of the export, this achievement once again broke the record, and a new champion was born...

Next.

It is a new drug for multiple sclerosis.

The extremely rare disease Creutzfeldt-Jakob disease is easily misdiagnosed as multiple sclerosis. Xu Qiu had no idea about Creutzfeldt-Jakob disease, which has a 100% mortality rate like rabies, but he also did a lot of research on multiple sclerosis during the research process.

This also allowed him to find a drug target.

And this new drug targets the target CD20-positive B cells.

The drug can selectively bind to the target without affecting stem cells or plasma cells. After intravenous administration, it can play a neuroprotective function, and the frequency of medication is once every six months. It can not only delay the progression of multiple sclerosis, but also improve the compliance of multiple sclerosis.

This is also the most expensive scientific research project among the ten achievements!