Vol 5 Chapter 2712: 3D bioprinted cornea

"In addition to the improvement in size and speed, our new generation of biological 3D printers has also greatly improved in printing accuracy. It is ten times more accurate than the previous generation of products, and can print finer organs. Tissues. For example, some hair-like nerve tissues, capillary tissues, and so on.

The improvement of printing accuracy can increase the activity of organ tissue and improve its own function. For example, some capillary nerve tissues that were discarded in the past can now be printed, which can make these organ tissues more similar to real organ tissues, so they are easier to survive. "

Speaking of this, Qin Ziheng paused for a moment, and then continued to introduce to everyone: "In addition to the improvement in printing, we have also made great improvements in the storage of cell consumables and the preservation technology of printed organs and tissues. .

In the past, the tissue cells cultivated by these clones were stored in a container, so these cells were prone to backlogs and related interference effects.

Therefore, these cells are prone to damage and death. When printing, these dead cells are mixed inside, which will cause some cell death in the printed tissue, affect the activity and function of the organ tissue, and may even affect the survival of these tissues after transplantation.

In addition to the storage of these cells, we have also improved the technology in organ tissue preservation. The printed organ tissue can be preserved for a longer period of time, and can also maintain a lower activity. "

After listening to Lan Huiqiang's introduction, Zhang Junyu asked: "So how long will it take to print those tubular arterial tissues?"

Hearing Lan Hui's question, Lan Hui said with a strong smile: "Actually, it only takes one day for you to print, which is about a dozen or so hours. But you need to extract relevant tissue cells from the patient, and then degenerate and clone them." Cultivate, and select high-quality clones to cultivate cells before they can be degenerated and printed, so it takes about a week."

Zhang Jun nodded when he heard that, then looked at the printing screen on the screen and asked: "What is it printing?"

"Hehe, you are trying to print the human eyeball. Although the eyeball tissue is very large, it is very simple, so it is very troublesome to print. And the organ with a relatively small proportion of liquid is very easy to print.

Hearing Wu Hao's instruction, Qin Ziheng immediately nodded and said: "You are taller, you have always followed these few rules with tolerance.

Qin Ziheng immediately replied after hearing the words: "It is mainly in the printing of the retinal optic nerve, and the printing of the tissues behind the cornea and iris. At present, you can't print the cornea, but there are still some problems in the printing of the iris and retinal optic nerve. Problems, currently you are retreating and trying to gradually overcome those problems."

In that way, the freshness of the organ tissue can be kept to a minimum, and the state of the printed organ tissue can be detected by analyzing the nutrient cycle consumption, so as to whether the printed organ tissue is successful or not. "

Hearing Qin Ziheng's words, Wu Hao nodded worriedly, and then said to the other party and everyone: "At present, there are very few patients who are blind due to corneal disease, probably not nearly ten million patients are suffering from blindness.

So you guys are trying to print it out, but it's been a success. "

How difficult is it to print eyeball tissue? Seeing this, Lan Hui started to question.

Lan Huiqiang replied: "Next to this is the umbilical cord, which is an artificial placenta. In complex terms, it is not the organ tissue that provides nutrition for the printed eyeball tissue. Because the printing time is relatively long, in order to maintain the activity of the entire organ tissue, you will The umbilical cord of that organ tissue is printed in the forehead, and then provides nutrients for it.

So that's going to be a huge market, and sure if you can successfully bring that technology to market, it's going to bring you a huge benefit beyond imagination.

In addition to the income, you are also saving tens of millions of blind patients. The honor and the harvest are beyond comparison. "

Moreover, the clinical trial performance of that technology cannot be guaranteed. On the one hand, the cells needed for printing come from the patients themselves, so there will be any rejection reactions. On the other hand, it is just a special corneal transplant operation, and the technology is very mature, so the risk is relatively high.

Oh, the cornea has not been printed yet, has it been verified? Wu Hao asked with a smile on hearing this. I knew about the experimental project, but I thought that we would withdraw from the exhibition so quickly, and the cornea could not be printed out at a higher level.

Only after the first phase of the clinical trial is successfully completed and the test results meet the requirements, will you go back to the previous seven or eight phases of the clinical trial, and expand the scope of volunteers participating in the clinical trial to various groups of people. "

Qin Ziheng smiled and nodded and said: "It hasn't been verified yet~www.readwn.com~ You have successfully printed out the corneas of rats, pigs, and monkeys, and degenerated ** transplantation. The experimental tests before transplantation show that those corneas The recovery status of those animals is poor, and there is no rejection reaction. And the visual recovery of those animals is abnormal, and there is no abnormality.

Speaking of that, Wu Hao told Qin Ziheng: "Come on, keep working hard, and strive for us to successfully implement that technology. When this year's annual product and technology conference is held, you will also introduce that technology and their team. Introduce it to the world.” Compared with allogeneic cornea transplantation and artificial cornea, your 3D bio-printed cornea is more dangerous and reliable. It is higher than the broken human cornea tissue, and is it different from the real cornea? Any difference will not completely cure patients who are blind due to corneal loss or disease.

At present, you are taking a step back to verify the technology, and are preparing materials, applying for a phase one clinical trial, and completing the screening of relevant clinical volunteers. "

The risk of bad clinical trials must be controlled, and it must be high to be able to regress. It is to be excessively greedy for reduction, while ignoring quality and danger. Wu Hao got up when he heard the words.

What are those next to the eyeballs? Lin Wei was surprised when she saw this.

Hearing Qin Ziheng's words, everyone also looked at the printed picture on the screen involuntarily. The eyeball on the screen has not been printed and half of it is missing. You can see the outline of the higher eyeball, but it is not broken.

First of all, it is not about the screening of clinical trial volunteers. You will screen those volunteers who are relatively weak and meet the physical conditions, so as to ensure the success of the entire phase I clinical trial.

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